Phylogenetic comparative methods comprise the general endeavor of using an estimated phylogenetic tree (or set of trees) to make secondary inferences: about trait evolution, diversification dynamics, biogeography, community ecology, and a wide range of other phenomena or processes.Over the past ten years or so, the phytools R package has grown to b
Abstract Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood.While many research avenues into the origins of SCZ during D-Sub/Serial brain development have been explored, the contribution of endothelial/vascular dysfunction to the disease remains largely elusive.
Trop-2 is a transmembrane signal transducer that can induce cancer growth.Using antibody targeting and N-terminal Edman degradation, we show here that Trop-2 undergoes cleavage in the first thyroglobulin domain loop of its extracellular region, between residues R87 and T88.Molecular modeling indicated that this cleavage induces a profound rearrange
The expansion of operation technology (OT) use and its tight integration with classical information and communication technologies have led not only to additional and improved possibilities in monitoring physical/manufacturing processes and the emergency of Industry 4.0 but also to a number of new threats, both related to the security of processed
One of the primary diseases that cause death worldwide is cancer.Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of Light Weight action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer.A pr